![]() This is due to a confluence of factors, including the limited regenerative capacity and overall complexity of the brain, problems associated with repeated drug administration, and difficulties delivering drugs across the blood-brain barrier (BBB). ![]() 5Center for Genomic and Computational Biology, Duke University Medical Center, Durham, NC, United Statesĭiseases of the central nervous system (CNS) have historically been among the most difficult to treat using conventional pharmacological approaches.4Department of Neurology, Division of Translational Brain Sciences, Duke University Medical Center, Durham, NC, United States.3Duke Center for Advanced Genomic Technologies, Durham, NC, United States.2Viral Vector Core, Duke University Medical Center, Durham, NC, United States.1Department of Neurobiology, Duke University Medical Center, Durham, NC, United States.Joseph Edward Rittiner 1,2,3†, Malik Moncalvo 1,2,3†, Ornit Chiba-Falek 4,5 and Boris Kantor 1,2,3*
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